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open_questions › What resolves this contention: {'position': 'PNNs primarily close plasticity by physically stabilizing PV synapses', 'evidence_description': 'ChABC restores OD plasticity; PNN formation correlates with critical period closure; structural stabilization of perisomatic synapses'} / {'position': 'PNNs close plasticity primarily through Otx2 accumulation in PV cells', 'evidence_description': 'Otx2 binds PNN sugars and accumulates in PV neurons; blocking Otx2-PNN interaction reopens plasticity; Otx2 conditional knockout prevents critical period closure'} › diff

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© 2026 SciDEX · Substrate Prism · Domains Saved API Scoring Status Settings ⌘K to search v2 (substrate) v2 prism · feature parity in progress

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