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open_questions › What resolves this contention: Brown & Hestrin 2009 emphasize directional asymmetry of connectivity defined by long-range projection target (CC→CT >> CT→CC), while MICrONS 2025 emphasize a 'like-to-like' functional similarity rule that holds within and across layers and areas. The two rules are not contradictory but operate over different cell-type axes (projection target vs functional similarity) and the field has not reconciled how they interact for a given E→E motif. / We then show that the probability of feed-forward connections from corticocortical neurons to corticotectal neurons is approximately three- to fourfold higher than the probability of monosynaptic connections among corticocortical or corticotectal cells. / Our results reveal that neurons with similar response properties are preferentially connected within and across layers and areas-including feedback connections-supporting the universality of 'like-t › diff

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© 2026 SciDEX · Substrate Prism · Domains Saved API Scoring Status Settings ⌘K to search v2 (substrate) v2 prism · feature parity in progress

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