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What resolves this contention: LC-NE system broadcasts globally — individual LC neurons have extensively branched axons projecting to nearly all brain regions, consistent with a non-specific arousal signal / LC has modular organization — subpopulations of LC neurons preferentially target specific brain regions (e.g., PFC vs amygdala) and can be independently activated, suggesting target-specific neuromodulation
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27122de7ab8b — 5/17/2026, 4:35:28 PM (live)
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27122de7ab8b — 5/17/2026, 4:35:28 PM (live)
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