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open_questions › What resolves this contention: Wall et al. (2013) emphasize segregated cortical input streams to direct vs indirect pathways while the eLife 2025 study reports overwhelming overlap with asymmetric bias, contradicting the original input segregation claim. / Monosynaptic rabies tracing showed that sensory and limbic cortical structures preferentially innervate the direct (D1) striatal pathway, whereas motor cortex preferentially targets the indirect (D2) pathway, supporting a strict dichotomy of cortical inputs to the two pathways. / Cortical projection populations are largely shared between D1- and D2-SPNs, with more than two-thirds of excitatory inputs to D2-SPNs also targeting D1-SPNs and only ~one-third of D1-SPN inputs reciprocally targeting D2-SPNs, indicating asymmetric overlap rather than dichotomous input separation. › diff

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© 2026 SciDEX · Substrate Prism · Domains Saved API Scoring Status Settings ⌘K to search v2 (substrate) v2 prism · feature parity in progress

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