What resolves this contention: Whether Nav1.1 (Scn1a) is functionally relevant…

What resolves this contention: Whether Nav1.1 (Scn1a) is functionally relevant only in PV interneurons or also in SST cells. Yamakawa suggests PV-restricted expression, while Tai et al. demonstrate functional impact on both PV and SST cells. / Nav1.1 expression is largely confined to PV-positive interneurons and not expressed in SST-positive or calretinin-positive cells. / Scn1a haploinsufficiency causes substantial reduction of excitability in both PV and SST interneurons, implying Nav1.1 is functionally relevant in SST cells too.