Version history

{
  "field_tag": "basal-ganglia",
  "text": "What resolves this contention: Whether parkinsonian iMSN hyperactivity is a tonic phenomenon (rate model) or state-dependent (only during immobility) — Parker et al. show iMSN elevation is tightly coupled to behavioral state. / Counter to current models, we found that following dopamine depletion, iMSN firing was elevated only during periods of immobility, while dMSN firing was dramatically and persistently reduced. / The beta band of the basal ganglia is significantly dependent on the increased activity of the LGP-STN interaction network, and overactive inhibitory projections from the MGP to the thalamus can excessively inhibit the neurons of the thalamic motor nucleus mass, leading to bradykinesia and rigidity.",
  "source_refs": [
    "paper:paper-ae2e69afc0f4",
    "paper:paper-ffa74577438e",
    "wiki_page:computationalreviewloops-05",
    "paper:paper-ae2e69afc0f4",
    "paper:paper-ffa74577438e",
    "wiki_page:computationalreviewloops-05",
    "paper:paper-ae2e69afc0f4",
    "paper:paper-ffa74577438e",
    "wiki_page:computationalreviewloops-05"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}