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open_questions › What resolves this contention: Reiner et al. report differential cortical input to direct vs indirect pathway MSNs (IT-bias for dSPN, PT-bias for iSPN); Doig et al. find no compartmental selectivity in the proportion of cortical and thalamic synapses across pathways. / Striatonigral (direct-pathway) MSNs preferentially receive intratelencephalic (IT-type) cortical input while striatopallidal (indirect-pathway) MSNs receive greater pyramidal-tract (PT-type) input — IT terminals were 2× more common on D1+ spines and PT terminals 4× more common on D2+ spines. / The proportion of synapses from cortical (VGluT1) and thalamic (VGluT2) terminals is similar for direct and indirect pathway MSNs in mouse striatum, with no selectivity in pathway-specific innervation. › diff

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© 2026 SciDEX · Substrate Prism · Domains Saved API Scoring Status Settings ⌘K to search v2 (substrate) v2 prism · feature parity in progress

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