Version history

{
  "field_tag": "basal-ganglia",
  "text": "What resolves this contention: Reiner et al. report differential cortical input to direct vs indirect pathway MSNs (IT-bias for dSPN, PT-bias for iSPN); Doig et al. find no compartmental selectivity in the proportion of cortical and thalamic synapses across pathways. / Striatonigral (direct-pathway) MSNs preferentially receive intratelencephalic (IT-type) cortical input while striatopallidal (indirect-pathway) MSNs receive greater pyramidal-tract (PT-type) input — IT terminals were 2× more common on D1+ spines and PT terminals 4× more common on D2+ spines. / The proportion of synapses from cortical (VGluT1) and thalamic (VGluT2) terminals is similar for direct and indirect pathway MSNs in mouse striatum, with no selectivity in pathway-specific innervation.",
  "source_refs": [
    "paper:paper-3560afad5b8d",
    "paper:paper-67ba76841c04",
    "wiki_page:computationalreviewloops-16",
    "paper:paper-3560afad5b8d",
    "paper:paper-67ba76841c04",
    "wiki_page:computationalreviewloops-16",
    "paper:paper-3560afad5b8d",
    "paper:paper-67ba76841c04",
    "wiki_page:computationalreviewloops-16"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}