Version history

{
  "field_tag": "neuroscience",
  "text": "What resolves this contention: Whether individual Kv3 subunit knockouts substantially impair the FS phenotype. Kv3.1 KO shows moderate impairment with redundancy, while Kv3.2 KO shows layer-specific substantial impairment. / Kv3.1 is not solely responsible for fast spikes or high-frequency firing in RTN neurons, as Kv3.1 knockout mice show only moderate impairment suggesting genetic redundancy. / Kv3.2 knockout causes impaired high-frequency firing specifically in deep-layer cortical FS interneurons where Kv3.2 is prominent, with increased seizure susceptibility.",
  "source_refs": [
    "paper:paper-08e60421a6c7",
    "paper:paper-f2a5716f0156",
    "wiki_page:computationalreviewpv-05",
    "paper:paper-08e60421a6c7",
    "paper:paper-f2a5716f0156",
    "wiki_page:computationalreviewpv-05",
    "paper:paper-08e60421a6c7",
    "paper:paper-f2a5716f0156",
    "wiki_page:computationalreviewpv-05"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}