Version history

{
  "field_tag": "vip-interneurons",
  "text": "What resolves this contention: Direction of VIP-IN activity change differs across autism-related models: Scn1a+/− Dravet/autism model shows reduced VIP-IN firing rate, whereas Fmr1−/− Fragile X model shows higher visually-evoked VIP activity (but with fewer VIP cells stimulus-responsive). Suggests that VIP dysfunction is bidirectional and gene-specific. / VIP-INs from Scn1a +/− mice fired at lower frequencies before application of carbachol (42 ± 2.9 vs. 34 ± 2.5 Hz, WT vs. / The mean magnitude of visually evoked activity of VIP cells was significantly higher in Fmr1 −/− mice than in WT mice ( Fig. 4E ), while the fraction of stimulus-responsive VIP cells was significantly",
  "source_refs": [
    "paper:paper-88bb0025c2ee",
    "paper:paper-ccfc44b19682",
    "wiki_page:computationalreviewvip-11-disease-translational",
    "paper:paper-88bb0025c2ee",
    "paper:paper-ccfc44b19682",
    "wiki_page:computationalreviewvip-11-disease-translational",
    "paper:paper-88bb0025c2ee",
    "paper:paper-ccfc44b19682",
    "wiki_page:computationalreviewvip-11-disease-translational"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}