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open_questions › What resolves this contention: Whether PV vs SST fate is rigidly determined by intrinsic transcription factor programs or can be dynamically influenced by the microenvironment even in postmitotic neurons / PV interneuron identity shows unexpected fate plasticity: lineage-traced postmitotic SST+ interneurons can upregulate PV when grafted onto human cortical models, suggesting environment dynamically shapes identity / COUP-TF1/TF2 autonomously repress PV+ fate in MGE progenitors through Sox6, suggesting cell-intrinsic transcriptional programs determine SST-PV fate › diff

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© 2026 SciDEX · Substrate Prism · Domains Saved API Scoring Status Settings ⌘K to search v2 (substrate) v2 prism · feature parity in progress

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