Version history

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  1. Live f7ff9056b6ad
    5/17/2026, 4:35:28 PM
    Content snapshot 
    {
  "field_tag": "neuroscience",
  "text": "What resolves this contention: Whether PV vs SST fate is rigidly determined by intrinsic transcription factor programs or can be dynamically influenced by the microenvironment even in postmitotic neurons / PV interneuron identity shows unexpected fate plasticity: lineage-traced postmitotic SST+ interneurons can upregulate PV when grafted onto human cortical models, suggesting environment dynamically shapes identity / COUP-TF1/TF2 autonomously repress PV+ fate in MGE progenitors through Sox6, suggesting cell-intrinsic transcriptional programs determine SST-PV fate",
  "source_refs": [
    "paper:paper-de3aae7294f5",
    "paper:paper-5fe32baac2c2",
    "wiki_page:computationalreviewpv-03",
    "paper:paper-de3aae7294f5",
    "paper:paper-5fe32baac2c2",
    "wiki_page:computationalreviewpv-03",
    "paper:paper-de3aae7294f5",
    "paper:paper-5fe32baac2c2",
    "wiki_page:computationalreviewpv-03"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}