What resolves this contention: Disagreement on the molecular mechanism of astrocytic glutamate release — regulated vesicular exocytosis (SNARE-dependent) versus non-vesicular channel permeation (Best1). / Astrocytic glutamate release is SNARE-protein dependent, i.e., proceeds via regulated vesicular exocytosis / Astrocytes release glutamate through the Bestrophin-1 (Best1) anion channel, which is highly glutamate-permeable and localizes to perisynaptic processes
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