Version history

{
  "field_tag": "basal-ganglia",
  "text": "What resolves this contention: Aponte et al. localize sufficiency for AGRP-evoked feeding to the AGRP soma without resolving the necessary downstream node, and explicitly show melanocortin signaling is not required for AGRP-evoked feeding. Atasoy et al. then assign the bulk of the acute feeding effect to the AGRP→PVH inhibitory projection (specifically AGRP suppression of PVH oxytocin neurons), narrowing the circuit substantially and challenging interpretations that ARC-only manipulations are sufficient explanations. / Activation of only 800 AGRP neurons in mice evoked voracious feeding within minutes. / An inhibitory circuit with paraventricular hypothalamus (PVH) neurons substantially accounted for acute AGRP neuron-evoked eating, whereas two other prominent circuits were insufficient.",
  "source_refs": [
    "paper:paper-c899e46ec4f7",
    "paper:paper-cd3b4df37fcb",
    "wiki_page:computationalreviewloops-09",
    "paper:paper-c899e46ec4f7",
    "paper:paper-cd3b4df37fcb",
    "wiki_page:computationalreviewloops-09",
    "paper:paper-c899e46ec4f7",
    "paper:paper-cd3b4df37fcb",
    "wiki_page:computationalreviewloops-09"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}