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open_questions › What resolves this contention: Astrocytes near amyloid plaques show calcium hyperactivity—elevated resting calcium, more frequent transients, long-range synchronous intercellular calcium waves, and uncoupling from neuronal activity vs. Astrocyte responses to amyloid-β pathology include both hypertrophic (potentially hyperactive) and atrophic (potentially hypoactive) morphological phenotypes, and the relationship between calcium and morphological changes may not be uniformly hyperactive / Astrocytic calcium transients in Alzheimer's mice are more frequent, synchronously coordinated across long distances, and uncoupled from neuronal activity. / Transplanted human iPSC-derived astrocytes underwent morphological changes becoming hypertrophic or atrophic in response to amyloid-β plaques in APP/PS1 chimeric mice, and these changes appeared independent of APOE allelic background (E3/E3 vs E4/E4). › diff

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