Version history

{
  "field_tag": "astrocytes",
  "text": "What resolves this contention: Astrocytes near amyloid plaques show calcium hyperactivity—elevated resting calcium, more frequent transients, long-range synchronous intercellular calcium waves, and uncoupling from neuronal activity vs. Astrocyte responses to amyloid-β pathology include both hypertrophic (potentially hyperactive) and atrophic (potentially hypoactive) morphological phenotypes, and the relationship between calcium and morphological changes may not be uniformly hyperactive / Astrocytic calcium transients in Alzheimer's mice are more frequent, synchronously coordinated across long distances, and uncoupled from neuronal activity. / Transplanted human iPSC-derived astrocytes underwent morphological changes becoming hypertrophic or atrophic in response to amyloid-β plaques in APP/PS1 chimeric mice, and these changes appeared independent of APOE allelic background (E3/E3 vs E4/E4).",
  "source_refs": [
    "paper:paper-2d9a059ff4a2",
    "paper:paper-41dc0509f7cf",
    "wiki_page:computationalreviewastrocytes-12",
    "paper:paper-2d9a059ff4a2",
    "paper:paper-41dc0509f7cf",
    "wiki_page:computationalreviewastrocytes-12",
    "paper:paper-2d9a059ff4a2",
    "paper:paper-41dc0509f7cf",
    "wiki_page:computationalreviewastrocytes-12",
    "paper:paper-2d9a059ff4a2",
    "paper:paper-41dc0509f7cf",
    "wiki_page:computationalreviewastrocytes-12"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}