What resolves this contention: Reactive astrocytes can be meaningfully classifi…

What resolves this contention: Reactive astrocytes can be meaningfully classified into neurotoxic A1 and neuroprotective A2 subtypes defined by distinct gene signatures; A1 astrocytes are induced by IL-1α/TNF/C1q, lose supportive functions, and kill neurons and oligodendrocytes vs. Binary A1/A2 divisions are insufficient and potentially misleading; reactive astrocytes exist along a multidimensional spectrum and should be characterized by multiple molecular and functional parameters with multivariate statistics / A1 astrocytes lose normal supportive functions and instead induce death of neurons and oligodendrocytes. / Binary divisions of reactive astrocytes into A1 versus A2 categories are insufficient, and research should instead assess multiple molecular and functional parameters with multivariate statistics.