Version history

{
  "field_tag": "vip-interneurons",
  "text": "What resolves this contention: NDNF (L1) interneurons as a parallel top-down regulator versus VIP-dependent disinhibition as the canonical top-down route / Layer 1 NDNF interneurons act as specialized top-down master regulators of cortical circuits, providing slow GABA-B inhibition onto pyramidal apical dendrites in parallel to (and partially independent of) VIP-mediated disinhibition. / Top-down disinhibition is canonically mediated by VIP→SST→pyramidal motifs, with NDNF/Lamp5 cells acting downstream/auxiliary rather than as parallel master regulators.",
  "source_refs": [
    "paper:paper-41c66384d08f",
    "paper:paper-733c0535ffcd",
    "wiki_page:computationalreviewvip-12-computational-models",
    "paper:paper-41c66384d08f",
    "paper:paper-733c0535ffcd",
    "wiki_page:computationalreviewvip-12-computational-models",
    "wiki_page:computationalreviewvip-13-conclusion",
    "paper:paper-41c66384d08f",
    "paper:paper-733c0535ffcd",
    "wiki_page:computationalreviewvip-12-computational-models",
    "wiki_page:computationalreviewvip-13-conclusion",
    "paper:paper-41c66384d08f",
    "paper:paper-733c0535ffcd",
    "wiki_page:computationalreviewvip-12-computational-models",
    "wiki_page:computationalreviewvip-13-conclusion",
    "paper:paper-41c66384d08f",
    "paper:paper-733c0535ffcd",
    "wiki_page:computationalreviewvip-12-computational-models",
    "wiki_page:computationalreviewvip-13-conclusion",
    "paper:paper-41c66384d08f",
    "paper:paper-733c0535ffcd",
    "wiki_page:computationalreviewvip-12-computational-models",
    "wiki_page:computationalreviewvip-13-conclusion"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}