What resolves this contention: Apparent paradox: Lhx6 is dispensable in adult P…

What resolves this contention: Apparent paradox: Lhx6 is dispensable in adult PV interneurons, yet its target SATB1 is essential for their maturation. This raises the question of when the Lhx6→SATB1 dependency window closes / Postnatal removal of Lhx6 does not affect PV interneuron number, morphology, or physiology - Lhx6 becomes uncoupled from downstream effectors in adulthood / SATB1 (a downstream target of Lhx6) is essential for PV interneuron maturation; Satb1 mutants show dramatic decrease in PV+ cells