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open_questions › What resolves this contention: Opposite reported sign of the net L2/3→L5 functional effect during whisker stimulation in mouse barrel cortex despite similar optogenetic L2/3 manipulations; second paper attributes the suppression to recruitment of SST interneurons by L2/3 activation. / Optogenetic activation of mouse barrel cortex L2/3 pyramidal neurons amplifies sensory-evoked L5 responses with velocity-dependent gain; deactivation suppresses L5 sensory responses (L2/3 → L5 is a feedforward excitation/gain-control pathway). / During active sensing in mouse barrel cortex, activating L2/3 predominantly suppresses spontaneous L5 activity and deactivating L2/3 mainly facilitates L5 touch responses — opposite signs of L2/3→L5 functional effect. › diff

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