Version history

{
  "field_tag": "excitatory-recurrence",
  "text": "What resolves this contention: Opposite reported sign of the net L2/3→L5 functional effect during whisker stimulation in mouse barrel cortex despite similar optogenetic L2/3 manipulations; second paper attributes the suppression to recruitment of SST interneurons by L2/3 activation. / Optogenetic activation of mouse barrel cortex L2/3 pyramidal neurons amplifies sensory-evoked L5 responses with velocity-dependent gain; deactivation suppresses L5 sensory responses (L2/3 → L5 is a feedforward excitation/gain-control pathway). / During active sensing in mouse barrel cortex, activating L2/3 predominantly suppresses spontaneous L5 activity and deactivating L2/3 mainly facilitates L5 touch responses — opposite signs of L2/3→L5 functional effect.",
  "source_refs": [
    "paper:paper-9360095f1258",
    "paper:paper-ec77beb36424",
    "wiki_page:computationalreviewrecurrence-04-translaminar",
    "paper:paper-9360095f1258",
    "paper:paper-ec77beb36424",
    "wiki_page:computationalreviewrecurrence-04-translaminar",
    "paper:paper-9360095f1258",
    "paper:paper-ec77beb36424",
    "wiki_page:computationalreviewrecurrence-04-translaminar",
    "paper:paper-9360095f1258",
    "paper:paper-ec77beb36424",
    "wiki_page:computationalreviewrecurrence-04-translaminar",
    "paper:paper-9360095f1258",
    "paper:paper-ec77beb36424",
    "wiki_page:computationalreviewrecurrence-04-translaminar",
    "paper:paper-9360095f1258",
    "paper:paper-ec77beb36424",
    "wiki_page:computationalreviewrecurrence-04-translaminar"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}