What resolves this contention: The SST-IRES-Cre off-target paper reports 6-10% recombination in fast-spiking PV+ interneurons, raising concerns about studies using this line. The PV/VIP-to-MC inhibition study uses Cre lines (including SST-Cre) for optogenetic experiments without extensively validating specificity, potentially confounding their circuit measurements.
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