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What resolves this contention: Whether persistent task-relevant cortical activity is held by reciprocal cortico-thalamic excitation or by thalamic gain modulation of intrinsic cortical recurrent dynamics. / Persistent activity is maintained by reciprocal excitation in a closed thalamocortical loop (ALM↔VM/VAL); thalamic inhibition produces near-complete collapse of cortical persistent activity. / Persistent rule representation in PFC is supported not by reciprocal cortico-thalamic excitation per se but by MD-driven amplification of intrinsic PFC connectivity that lets the representation emerge cortically.
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0371872e5ced — 5/17/2026, 4:35:28 PM (live)
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0371872e5ced — 5/17/2026, 4:35:28 PM (live)
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