Version history

{
  "field_tag": "astrocytes",
  "text": "What resolves this contention: Apparent cell-type conflict about which glial cell is the relevant TNF-α source for plasticity: cortical homeostatic scaling is attributed to astrocyte-derived TNF (Stellwagen/Malenka lineage, confirmed by cell-specific conditional knockout in 2024), while striatal drug-induced plasticity is attributed to microglia-derived TNF. / Astrocytes are the necessary source of TNF-α that mediates homeostatic synaptic plasticity (synaptic scaling) in visual cortex, with conditional astrocyte-specific TNF deletion phenocopying global TNF knockout. / Striatal microglia, not astrocytes, are the source of TNF-α that suppresses cocaine-induced plasticity — microglial activation and TNF production drive AMPAR internalization on medium spiny neurons, and depleting microglia abolishes this regulation.",
  "source_refs": [
    "paper:paper-9dcbd83d4103",
    "paper:paper-f0ba4695e5a5",
    "wiki_page:computationalreviewastrocytes-08",
    "paper:paper-9dcbd83d4103",
    "paper:paper-f0ba4695e5a5",
    "wiki_page:computationalreviewastrocytes-08",
    "paper:paper-9dcbd83d4103",
    "paper:paper-f0ba4695e5a5",
    "wiki_page:computationalreviewastrocytes-08",
    "paper:paper-9dcbd83d4103",
    "paper:paper-f0ba4695e5a5",
    "wiki_page:computationalreviewastrocytes-08"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}