Version history

{
  "field_tag": "astrocytes",
  "text": "What resolves this contention: iPSC-derived astrocytes can be generated at high efficiency, express appropriate markers (S100β, GFAP), exhibit regional patterning, integrate with vasculature in vivo, and recapitulate disease-relevant phenotypes such as elevated Cx43 in ALS vs. iPSC-derived astrocytes and cortical organoid astrocytes transcriptionally correspond to mid-fetal developmental stages (19–24 post-conception weeks) and may not fully mature to adult human astrocyte states, raising concerns about modeling late-onset diseases / Human pluripotent stem cells can be directed to nearly uniform populations of immature astrocytes expressing S100β and GFAP at high efficiency. / Human cortical spheroids (hCSs) generated from pluripotent stem cells contain both deep and superficial cortical layer neurons and transcriptionally map to mid-fetal prenatal brain development (19–24 post-conception weeks).",
  "source_refs": [
    "paper:paper-374a998f7856",
    "paper:paper-a9b076f3b9d0",
    "wiki_page:computationalreviewastrocytes-12",
    "paper:paper-374a998f7856",
    "paper:paper-a9b076f3b9d0",
    "wiki_page:computationalreviewastrocytes-12",
    "paper:paper-374a998f7856",
    "paper:paper-a9b076f3b9d0",
    "wiki_page:computationalreviewastrocytes-12",
    "paper:paper-374a998f7856",
    "paper:paper-a9b076f3b9d0",
    "wiki_page:computationalreviewastrocytes-12"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}