Version history
1 version on record. Newest first; the live version sits at the top with a live indicator.
- Live5/17/2026, 4:35:28 PM
43605b35a0cdContent snapshot
{ "field_tag": "vip-interneurons", "text": "What resolves this contention: Behavioral state modulation: VIP-driven disinhibition vs cell-type-context-dependent inhibition / Fu et al. 2014 (Cell) and Pi et al. 2013 promote a model where locomotion/arousal acts via VIP-driven disinhibition through SST suppression. Reimer/Dipoppa et al. 2018 ('Behavioral-state modulation of inhibition is context-dependent and cell type specific') showed the directionality of behavioral-state modulation differs across PV/SST/VIP and depends on cortical area and stimulus context, complicating a single canonical disinhibitory motif. / Fu et al. 2014 (Cell) and Pi et al. 2013 promote a model where locomotion/arousal acts via VIP-driven disinhibition through SST suppression. Reimer/Dipoppa et al. 2018 ('Behavioral-state modulation of inhibition is context-dependent and cell type specific') showed the directionality of behavioral-state modulation differs across PV/SST/VIP and depends on", "source_refs": [ "paper:paper-065a0eae69a5", "paper:paper-5cfe39bf225d", "wiki_page:computationalreviewvip-01-introduction", "paper:paper-065a0eae69a5", "paper:paper-5cfe39bf225d", "wiki_page:computationalreviewvip-01-introduction", "wiki_page:computationalreviewvip-02-classification", "paper:paper-065a0eae69a5", "paper:paper-5cfe39bf225d", "wiki_page:computationalreviewvip-01-introduction", "wiki_page:computationalreviewvip-02-classification", "wiki_page:computationalreviewvip-06-synaptic-properties", "paper:paper-065a0eae69a5", "paper:paper-5cfe39bf225d", "wiki_page:computationalreviewvip-01-introduction", "wiki_page:computationalreviewvip-02-classification", "wiki_page:computationalreviewvip-06-synaptic-properties", "wiki_page:computationalreviewvip-07-disinhibition-framework", "paper:paper-065a0eae69a5", "paper:paper-5cfe39bf225d", "wiki_page:computationalreviewvip-01-introduction", "wiki_page:computationalreviewvip-02-classification", "wiki_page:computationalreviewvip-06-synaptic-properties", "wiki_page:computationalreviewvip-07-disinhibition-framework", "paper:paper-065a0eae69a5", "paper:paper-5cfe39bf225d", "wiki_page:computationalreviewvip-01-introduction", "wiki_page:computationalreviewvip-02-classification", "wiki_page:computationalreviewvip-06-synaptic-properties", "wiki_page:computationalreviewvip-07-disinhibition-framework", "paper:paper-065a0eae69a5", "paper:paper-5cfe39bf225d", "wiki_page:computationalreviewvip-01-introduction", "wiki_page:computationalreviewvip-02-classification", "wiki_page:computationalreviewvip-06-synaptic-properties", "wiki_page:computationalreviewvip-07-disinhibition-framework", "paper:paper-065a0eae69a5", "paper:paper-5cfe39bf225d", "wiki_page:computationalreviewvip-01-introduction", "wiki_page:computationalreviewvip-02-classification", "wiki_page:computationalreviewvip-06-synaptic-properties", "wiki_page:computationalreviewvip-07-disinhibition-framework", "paper:paper-065a0eae69a5", "paper:paper-5cfe39bf225d", "wiki_page:computationalreviewvip-01-introduction", "wiki_page:computationalreviewvip-02-classification", "wiki_page:computationalreviewvip-06-synaptic-properties", "wiki_page:computationalreviewvip-07-disinhibition-framework", "paper:paper-065a0eae69a5", "paper:paper-5cfe39bf225d", "wiki_page:computationalreviewvip-01-introduction", "wiki_page:computationalreviewvip-02-classification", "wiki_page:computationalreviewvip-06-synaptic-properties", "wiki_page:computationalreviewvip-07-disinhibition-framework", "paper:paper-065a0eae69a5", "paper:paper-5cfe39bf225d", "wiki_page:computationalreviewvip-01-introduction", "wiki_page:computationalreviewvip-02-classification", "wiki_page:computationalreviewvip-06-synaptic-properties", "wiki_page:computationalreviewvip-07-disinhibition-framework", "paper:paper-065a0eae69a5", "paper:paper-5cfe39bf225d", "wiki_page:computationalreviewvip-01-introduction", "wiki_page:computationalreviewvip-02-classification", "wiki_page:computationalreviewvip-06-synaptic-properties", "wiki_page:computationalreviewvip-07-disinhibition-framework" ], "importance": "0.7200", "tractability": "0.5500", "potential_impact": "0.7000", "composite_score": "0.2772", "elo_rating": "1500.00", "state": "open", "decay_rate": "0.01000", "resolution_evidence_refs": [] }