Version history

{
  "field_tag": "basal-ganglia",
  "text": "What resolves this contention: Optogenetic gain-of-function in Kravitz et al. supports the classical antagonism model whereas natural-activity recording in Cui et al. observes concurrent activation, suggesting that artificial bilateral pathway-isolated stimulation does not reflect normal coordinated CBGTC dynamics. / Optogenetic excitation of D1-Cre direct-pathway MSNs and D2-Cre indirect-pathway MSNs produces opposing motor phenotypes (locomotion vs parkinsonism), supporting strict pathway antagonism in motor control. / Fiber photometry recordings in D1-Cre and A2A-Cre mice show that direct- and indirect-pathway SPNs are CONCURRENTLY (not antagonistically) activated immediately before action initiation, challenging the strict opposing-pathway interpretation.",
  "source_refs": [
    "paper:5c30e0b5-d627-4661-b656-d88df1b47830",
    "paper:paper-10_1038_nature11846",
    "wiki_page:computationalreviewloops-11",
    "paper:5c30e0b5-d627-4661-b656-d88df1b47830",
    "paper:paper-10_1038_nature11846",
    "wiki_page:computationalreviewloops-11",
    "paper:5c30e0b5-d627-4661-b656-d88df1b47830",
    "paper:paper-10_1038_nature11846",
    "wiki_page:computationalreviewloops-11"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}