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open_questions › What resolves this contention: Anatomical IT vs PT corticostriatal distinction is graded with substantial overlap (single-axon morphology) yet functional/synaptic IT vs PT distinction is sharp at the network level (cholinergic-mediated polysynaptic motif). / When matched on samples reconstructed in MouseLight, IT and PT cortical neurons have largely overlapping distributions of ipsilateral striatal axonal end-points, undermining a sharp IT-extended-vs-PT-focal anatomical dichotomy. / PT corticostriatal inputs are functionally distinct from IT inputs, generating biphasic, ChI-mediated signals to spiny projection neurons that are absent in IT inputs — implying robust class-specific corticostriatal organization. › diff

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