What resolves this contention: Whether L-DOPA-induced dyskinesia arises primari…

What resolves this contention: Whether L-DOPA-induced dyskinesia arises primarily from serotonergic ectopic dopamine release versus intrinsic striatal medium spiny neuron plasticity (ΔFosB pathway). / L-DOPA-induced dyskinesia depends critically on aberrant dopamine release from serotonergic projections to the striatum. / L-DOPA-induced dyskinesia is causally driven by chronic accumulation of ΔFosB and maladaptive striatal plasticity in medium spiny neurons.