Version history

{
  "field_tag": "astrocytes",
  "text": "What resolves this contention: Smith et al. 2017 report no AQP4 effect; Mestre et al. 2018, a multi-laboratory response study, re-establish AQP4-dependence and attribute discrepancies to anesthesia, age, and tracer-delivery differences. / Aqp4 gene deletion did not impair transport of fluorescent solutes from sub-arachnoid space to brain in mice or rats, arguing against AQP4-dependent glymphatic transport. / Five groups re-examined AQP4; CSF influx is higher in wild-type mice than in four different Aqp4 KO lines and in one line that lacks perivascular AQP4 (Snta1 KO); meta-analysis demonstrated a significant decrease in tracer transport in KO mice and rats compared to controls.",
  "source_refs": [
    "paper:paper-ce55e5b61723",
    "paper:paper-189f19af1d54",
    "wiki_page:computationalreviewastrocytes-05",
    "paper:paper-ce55e5b61723",
    "paper:paper-189f19af1d54",
    "wiki_page:computationalreviewastrocytes-05",
    "paper:paper-ce55e5b61723",
    "paper:paper-189f19af1d54",
    "wiki_page:computationalreviewastrocytes-05",
    "paper:paper-ce55e5b61723",
    "paper:paper-189f19af1d54",
    "wiki_page:computationalreviewastrocytes-05"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}