Version history

{
  "field_tag": "basal-ganglia",
  "text": "What resolves this contention: Whether direct and indirect SPN pathways operate in opposition or are co-activated. The DA-bias study supports an opponent push-pull architecture (DA shifts the balance), while the calcium-imaging study reports concurrent activation of both populations during movement initiation, undermining strict opposition. / We find that increasing and decreasing DA biases striatal activity toward the direct and indirect pathways, respectively, by changing the overall number of SPNs recruited during behavior in a manner not predicted by existing models of DA function. / Concurrent activation of SPNs from both pathways in one hemisphere preceded the initiation of contraversive movements, and predicted the occurrence of specific movements within 500 ms.",
  "source_refs": [
    "paper:paper-10_1038_nature11846",
    "paper:paper-94a1876c7046",
    "wiki_page:computationalreviewloops-03",
    "paper:paper-10_1038_nature11846",
    "paper:paper-94a1876c7046",
    "wiki_page:computationalreviewloops-03",
    "paper:paper-10_1038_nature11846",
    "paper:paper-94a1876c7046",
    "wiki_page:computationalreviewloops-03"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}