Version history

{
  "field_tag": "excitatory-recurrence",
  "text": "What resolves this contention: Whether mouse-to-primate differences in corticospinal/PT architecture are present at the level of cell-type identity vs only at the level of late developmental wiring. The first paper shows that the cortico-motoneuronal connection is transiently present in mice (i.e., the wiring difference is developmental), while the cross-species transcriptomic atlas frames pyramidal-class differences as molecular/cell-type specializations. / Previously thought to be specific to higher primates, we identified transient CM connections in early postnatal mice, which are eventually eliminated by Sema6D-PlexA1 signaling.mutant mice maintain CM connections into adulthood and exhibit superior manual dexterity as compared with that of controls. / Despite the overall conservation, however, many species-dependent specializations are apparent, including differences in cell-type proportions, gene expression, DNA ",
  "source_refs": [
    "paper:paper-5095a8dd70d7",
    "paper:paper-pm-34616062",
    "wiki_page:computationalreviewrecurrence-02-anatomy-primer",
    "paper:paper-5095a8dd70d7",
    "paper:paper-pm-34616062",
    "wiki_page:computationalreviewrecurrence-02-anatomy-primer",
    "paper:paper-5095a8dd70d7",
    "paper:paper-pm-34616062",
    "wiki_page:computationalreviewrecurrence-02-anatomy-primer"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}