Version history

{
  "field_tag": "astrocytes",
  "text": "What resolves this contention: Astrocyte-derived complement C3 is a hallmark of the neurotoxic A1 reactive state and is upregulated in AD, Parkinson's, and other neurodegenerative diseases; C3+ reactive astrocytes are abundant in human post-mortem tissue vs. Genetic deletion of C3 is neuroprotective in APP/PS1 mice—preventing cognitive decline and hippocampal neuron loss—despite increasing amyloid plaque burden, indicating complement-mediated neuroinflammation rather than amyloid itself drives neurodegeneration / A1 reactive astrocytes are abundant in human post-mortem tissue from Alzheimer's, Huntington's, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. / C3 deficiency protected aged APP/PS1 mice against cognitive decline despite increased amyloid plaque burden.",
  "source_refs": [
    "paper:paper-290ca86a608f",
    "paper:e34924e9-6767-42c2-aec6-a464c23d03c7",
    "wiki_page:computationalreviewastrocytes-12",
    "paper:paper-290ca86a608f",
    "paper:e34924e9-6767-42c2-aec6-a464c23d03c7",
    "wiki_page:computationalreviewastrocytes-12",
    "paper:paper-a83e8d05b731",
    "paper:paper-290ca86a608f",
    "paper:e34924e9-6767-42c2-aec6-a464c23d03c7",
    "wiki_page:computationalreviewastrocytes-12",
    "paper:paper-a83e8d05b731",
    "paper:paper-290ca86a608f",
    "paper:e34924e9-6767-42c2-aec6-a464c23d03c7",
    "wiki_page:computationalreviewastrocytes-12",
    "paper:paper-a83e8d05b731"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}