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What resolves this contention: Reconciliation depends on stimulus context and brain state. Disinhibition is one of several VIP-mediated motifs.; confidence: high; additional_dois: ['10.1126/science.1254126', '10.1016/j.neuron.2018.03.037', '10.7554/elife.14985'] / VIP interneuron activity gates sensory cortical pyramidal-cell gain via SST disinhibition (a 'disinhibitory' model: VIP→SST→Pyr). / Locomotion in mouse V1 elevates SST activity along with VIP, increasing inhibitory drive onto Pyr cells when visual stimuli are present, contradicting a simple disinhibitory model and indicating context-dependent SST recruitment.
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e60e3543c0ea — 5/17/2026, 4:35:28 PM (live)
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e60e3543c0ea — 5/17/2026, 4:35:28 PM (live)
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