Version history

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  1. Live e60e3543c0ea
    5/17/2026, 4:35:28 PM
    Content snapshot 
    {
  "field_tag": "vip-interneurons",
  "text": "What resolves this contention: Reconciliation depends on stimulus context and brain state. Disinhibition is one of several VIP-mediated motifs.; confidence: high; additional_dois: ['10.1126/science.1254126', '10.1016/j.neuron.2018.03.037', '10.7554/elife.14985'] / VIP interneuron activity gates sensory cortical pyramidal-cell gain via SST disinhibition (a 'disinhibitory' model: VIP→SST→Pyr). / Locomotion in mouse V1 elevates SST activity along with VIP, increasing inhibitory drive onto Pyr cells when visual stimuli are present, contradicting a simple disinhibitory model and indicating context-dependent SST recruitment.",
  "source_refs": [
    "paper:paper-065a0eae69a5",
    "paper:paper-f02f24cb44ff",
    "wiki_page:computationalreviewvip-06-synaptic-properties",
    "paper:paper-065a0eae69a5",
    "paper:paper-f02f24cb44ff",
    "wiki_page:computationalreviewvip-06-synaptic-properties",
    "paper:paper-065a0eae69a5",
    "paper:paper-f02f24cb44ff",
    "wiki_page:computationalreviewvip-06-synaptic-properties"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}