What resolves this contention: Generalizability of the Frank D1/D2 model prediction across PD heterogeneity — Brain 2020 contests the universal applicability of the carrot/stick effect. / Levodopa universally reverses Parkinson's negative learning bias to a positive bias across PD patients. / Levodopa enhancement of reinforcement learning is restricted to non-tremor PD subtypes; tremor-dominant patients show no levodopa effect.
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