Version history

{
  "field_tag": "basal-ganglia",
  "text": "What resolves this contention: GPe activity changes in LID — empirical recordings show GPe firing increases during dyskinesia (consistent with indirect-pathway disinhibition), but the simple LID model predicts indirect-pathway suppression which would lower (not raise) GPe firing. / Spontaneous firing rates of GPe neurons were decreased in the dyskinesia-off state (≥24 h after l-DOPA injection) and increased in the dyskinesia-on state (20-100 min after l-DOPA injection while showing dyskinesia), while those of SNr neurons showed no significant changes. / While in LID the DA concentration in the striatum is increased, which enhances the output of direct pathway by the stimulation of D 1 receptor, the indirect pathway is inhibited via the activation of D 2 receptor.",
  "source_refs": [
    "paper:paper-4b8dc0997161",
    "paper:paper-d9bb19ffc604",
    "wiki_page:computationalreviewloops-05",
    "paper:paper-4b8dc0997161",
    "paper:paper-d9bb19ffc604",
    "wiki_page:computationalreviewloops-05",
    "paper:paper-4b8dc0997161",
    "paper:paper-d9bb19ffc604",
    "wiki_page:computationalreviewloops-05"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}