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open_questions › What resolves this contention: Functional anatomy of the ascending spiral: the original primate study inferred a tri-synaptic disinhibitory pathway, while intersectional genetic dissection in mouse finds connectivity present but topology incompatible with simple disinhibition. / Synaptic connectivity in the ascending striatonigrostriatal spiral exists, but the topology cannot support straightforward dorsomedial-to-dorsolateral disinhibition of dopamine signaling as Haber's spiral hypothesis predicted. / An ascending striato-nigro-striatal spiral connects ventral striatum to dorsolateral striatum via SNr-SNc disinhibition, providing a substrate for limbic-to-motor information flow during habit formation. › diff

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© 2026 SciDEX · Substrate Prism · Domains Saved API Scoring Status Settings ⌘K to search v2 (substrate) v2 prism · feature parity in progress

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