Version history

{
  "field_tag": "basal-ganglia",
  "text": "What resolves this contention: The Alexander/DeLong parallel-loop framework localizes basal-ganglia disorder pathophysiology to striatal dopamine deficits within segregated circuits; the 2023 review reports that striatal DA loss alone is insufficient and extra-striatal DA modulation is causally required for parkinsonian motor deficits. / Parallel, segregated cortico-basal-ganglia-thalamocortical circuits originate in distinct cortical territories and remain functionally segregated through the striatum and thalamus, with motor symptoms in basal-ganglia disorders attributable to disruption of striatal dopaminergic signaling. / Striatal dopamine depletion alone is not sufficient to induce parkinsonism; restoration of extra-striatal dopamine signaling attenuates motor deficits, indicating that PD circuit pathophysiology cannot be localized to a single striatal node within the parallel-loop framework.",
  "source_refs": [
    "paper:paper-5efeb34044d1",
    "paper:paper-d9d769bfb55d",
    "wiki_page:computationalreviewloops-16",
    "paper:paper-5efeb34044d1",
    "paper:paper-d9d769bfb55d",
    "wiki_page:computationalreviewloops-16",
    "paper:paper-5efeb34044d1",
    "paper:paper-d9d769bfb55d",
    "wiki_page:computationalreviewloops-16"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}