What resolves this contention: The two landmark serial-EM quantitative studies report substantially different fractions of synapses contacted by perisynaptic astrocyte processes, differing by roughly 25 percentage points. / Only ~57±11% of hippocampal CA1 stratum radiatum synapses have astrocytic processes apposed to them, and those processes surround less than half of the synaptic interface. / Approximately 81% of cortical (motor cortex) dendritic spines are PAP-contacted, leaving only ~19% PAP-negative.
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