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open_questions › What resolves this contention: The simple VIP-mediated disinhibition model is contested: locomotion activates all interneuron types simultaneously rather than producing a clean disinhibitory cascade, suggesting the circuit operation is context-dependent / VIP interneurons mediate disinhibition by suppressing SOM and PV interneurons, creating a VIP→SOM/PV→pyramidal disinhibitory cascade that increases pyramidal cell gain during reinforcement / During locomotion with visual stimulation, VIP, SST, and PV interneurons all increase activity, challenging the simple disinhibition model where VIP activation leads to reduced SOM/PV firing › diff

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