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What resolves this contention: Whether human in vivo data support strict parallel-loop topography (Postuma & Dagher 2006 meta-analysis) or substantial regionally specific convergence violating that topography (Lehrhoff/Makris 2021). / Frontostriatal wiring deviates from strict topographic organization due to convergent fiber clusters from ventrolateral, dorsolateral, and orbitofrontal PFC. / Cortico-striatal functional connectivity broadly supports the parallel-loop model with rostrocaudal and dorsoventral topographic patterns reproducing predictions.
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May 16, 2026
Updated
May 17, 2026

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