Version history

{
  "field_tag": "basal-ganglia",
  "text": "What resolves this contention: Whether SPN-SPN lateral inhibition is functionally important for shaping striatal output (Burke), versus a striatal model where the dichotomy of D1/D2 SPN populations and their differential dopamine modulation is the dominant organizing principle (Surmeier). The two views are not mutually exclusive but differ in what is treated as primary. / The emphasis of this Perspective is on the underappreciated role of lateral inhibition between striatal projection cells in controlling neuronal firing and shaping the output of this circuit. / Recent advances in the means of marking neural circuits with optical or molecular reporters have revealed a clear-cut dichotomy between these two cell types at the molecular, anatomical, and physiological levels.",
  "source_refs": [
    "paper:paper-110c10365f14",
    "paper:paper-c82c5468c0b5",
    "wiki_page:computationalreviewloops-04",
    "paper:paper-110c10365f14",
    "paper:paper-c82c5468c0b5",
    "wiki_page:computationalreviewloops-04",
    "paper:paper-110c10365f14",
    "paper:paper-c82c5468c0b5",
    "wiki_page:computationalreviewloops-04"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}