What resolves this contention: Disagreement about the validity of dMRI tractogr…

What resolves this contention: Disagreement about the validity of dMRI tractography for inferring whole-brain structural connectivity: simulation challenge highlights pervasive false positives, whereas direct primate validation reports significant tract-tracing/dMRI correlations. / On a simulated whole-brain phantom, ~36% of tractography streamlines connected regions that were not actually connected; tractograms contained more invalid than valid bundles. / In rhesus macaque, dMRI streamline counts correlate positively (P<0.001) with retrograde tract-tracing FLN strengths from CoCoMac and Markov, supporting dMRI NOS as a valid measure of projection strength.