Version history

{
  "field_tag": "excitatory-recurrence",
  "text": "What resolves this contention: Both invoke presynaptic NMDARs at cortical t-LTD, but disagree on whether the receptor signals through Ca-flux (canonical ionotropic) or non-ionotropically — implying different mechanistic categories for ostensibly the same form of cortical t-LTD. / We conclude that neocortical L5 PC→PC tLTD relies on non-ionotropic preNMDAR signaling via JNK2/STX1a. / Moreover, whereas t-LTD at vertical inputs requires presynaptic NMDA receptors and is expressed presynaptically, using paired recordings we find that t-LTD at horizontal inputs requires postsynaptic NMDA receptors and is expressed postsynaptically.",
  "source_refs": [
    "paper:paper-2838da5fb3b7",
    "paper:paper-4dc12b2ece86",
    "wiki_page:computationalreviewrecurrence-12-plasticity",
    "paper:paper-2838da5fb3b7",
    "paper:paper-4dc12b2ece86",
    "wiki_page:computationalreviewrecurrence-12-plasticity",
    "paper:paper-2838da5fb3b7",
    "paper:paper-4dc12b2ece86",
    "wiki_page:computationalreviewrecurrence-12-plasticity",
    "paper:paper-2838da5fb3b7",
    "paper:paper-4dc12b2ece86",
    "wiki_page:computationalreviewrecurrence-12-plasticity",
    "paper:paper-2838da5fb3b7",
    "paper:paper-4dc12b2ece86",
    "wiki_page:computationalreviewrecurrence-12-plasticity",
    "paper:paper-2838da5fb3b7",
    "paper:paper-4dc12b2ece86",
    "wiki_page:computationalreviewrecurrence-12-plasticity"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}