Version history

{
  "field_tag": "basal-ganglia",
  "text": "What resolves this contention: Reiner et al 2004 in rat report differential cortical input to direct vs indirect MSNs (IT- vs PT-type biased), implying differential excitatory innervation of the two pathways. Doig et al 2010 in mouse find that the proportion of cortical (VGluT1) and thalamic (VGluT2) terminals onto D1- and D2-MSNs is the same. The disagreement turns on whether direct- and indirect-pathway MSNs are differentially innervated by glutamatergic inputs at the population level. / Finally, we combined selective BDA labeling of IT-type or PT-type terminals with immunolabeling for D1 or D2, and found that IT-type terminals were twice as common as PT-type on D1+ spines, whereas PT-type terminals were four times as common as IT-type on D2+ spines. / We found that the proportion of synapses formed by terminals derived from the cortex and thalamus was similar for both direct and indirect pathway MSNs.",
  "source_refs": [
    "paper:paper-3560afad5b8d",
    "paper:paper-67ba76841c04",
    "wiki_page:computationalreviewloops-02",
    "paper:paper-3560afad5b8d",
    "paper:paper-67ba76841c04",
    "wiki_page:computationalreviewloops-02",
    "paper:paper-3560afad5b8d",
    "paper:paper-67ba76841c04",
    "wiki_page:computationalreviewloops-02"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}