Version history

{
  "field_tag": "basal-ganglia",
  "text": "What resolves this contention: Patient age (pediatric vs adult); medication exposure differences — The two ENIGMA-OCD analyses agree that age-of-onset modulates structural endophenotypes: pediatric OCD has enlarged thalamus, adult OCD has subtle hippocampal/pallidal differences. The conflict is interpretive rather than empirical and points to neurodevelopmental trajectory. / The pediatric mega-analysis showed larger thalamus volume\nin OCD based on the main group comparison, whereas the\nmeta-analysis showed this only in unmedicated pediatric\nOCD patients compared with controls. / In the subcortical analyses, we found clear differences between the pediatric OCD patients (compared with healthy controls, n = 335 and 287, respectively) and the adult OCD patients (compared with healthy controls, n = 1,495 and 1,472, respectively) (Boedhoe et al., ).",
  "source_refs": [
    "paper:paper-2eb69cd030d6",
    "paper:paper-fd077ba68027",
    "wiki_page:computationalreviewloops-14",
    "paper:paper-2eb69cd030d6",
    "paper:paper-fd077ba68027",
    "wiki_page:computationalreviewloops-14",
    "paper:paper-2eb69cd030d6",
    "paper:paper-fd077ba68027",
    "wiki_page:computationalreviewloops-14"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}