Version history

{
  "field_tag": "excitatory-recurrence",
  "text": "What resolves this contention: Interpretation of paradoxical-effect experiments as a diagnostic of recurrent E→E coupling: Sanzeni 2020 uses wide-field VGAT activation (perturbing all inhibitory cells) to demonstrate ISN regime, but the same authors' 2020 theory paper shows that in realistic multi-interneuron networks the paradoxical effect alone does not uniquely identify an ISN. / Mouse V1, S1, and motor cortex operate as ISNs during spontaneous activity, with strong recurrent E→E gain demonstrated by paradoxical responses to widespread VGAT-ChR2 optogenetic inhibition. / In four-population networks including PYR/PV/SST/VIP, the paradoxical effect to PV perturbation can occur even when the network is NOT in the ISN regime — so paradoxical response is not a unique signature of strong recurrent E→E gain.",
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    "paper:paper-d6edd2b57842",
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    "wiki_page:computationalreviewrecurrence-09-amplification-isn",
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    "wiki_page:computationalreviewrecurrence-09-amplification-isn",
    "wiki_page:computationalreviewrecurrence-10-persistent-activity",
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    "paper:paper-38fe71bdf9b6",
    "paper:paper-d6edd2b57842",
    "wiki_page:computationalreviewrecurrence-09-amplification-isn",
    "wiki_page:computationalreviewrecurrence-10-persistent-activity"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}