What resolves this contention: Whether PV interneuron dysfunction in Dravet syn…

What resolves this contention: Whether PV interneuron dysfunction in Dravet syndrome is permanent or transient. Tai et al. show substantial reduction at one time point; Favero et al. demonstrate recovery, suggesting a developmental window. / Scn1a haploinsufficiency causes substantial, persistent reduction of excitability in PV and SST interneurons in Dravet syndrome mice. / Fast-spiking interneuron dysfunction in Scn1a+/- mice is transient, occurring during a developmental window with recovery by P35.