What resolves this contention: PSD-95 KO data argue brief MD's structural effec…

What resolves this contention: PSD-95 KO data argue brief MD's structural effect on adult V1 spines depends only on a single molecule's loss (silent-synapse persistence), while higher-visual-area imaging shows MD effects vary across visual areas and across deprived-/open-eye contributions — implying area- and molecule-specific gates on the same canonical OD plasticity model. / Under basal conditions, spine formation and elimination ratios were similar between PSD-95 knockout (KO) and wild-type (WT) mice. / OD shifts following MD were greatest in LM and smallest in AL and PM; in LM and AL, these shifts were mediated primarily through a reduction of deprived-eye responses, in V1b and LM through an increase in response through the non-deprived eye.